My choice for my computers. Antivirus + Antispyware + Firewall. For Windows XP, Windows 2000SP4, Windows Server 2003/2008, Windows Vista, and Windows 7, including 64-bit versions.
Vipre Premium which includes their new firewall and WinPatrol.
WinPatrol monitors the computer for installation of auto-running programs, changes to certain system settings, allows you to control auto-starting programs, to delay auto-starting programs, and has many more functions.
There is a free version, but I recommend the paid version, which includes access to BillP's database of program information.